Liver Perfusion in Sepsis, Septic Shock, and Multiorgan Failure

Liver perfusion in sepsis, septic shock, and multiorgan failure.

Sepsis causes significant alterations in the hepatic macro- and microcirculation. Diverging views exist on global hepatic blood flow during experimental sepsis because of the large variety in animal and sepsis models. Fluid-resuscitated clinical sepsis is characterized by ongoing liver ischemia due to a defective oxygen extraction despite enhanced perfusion. The effects of vasoactive agents on ...

Sepsis and Septic Shock

Septic shock (shock due to infection) and sepsis-associated multiple organ failure are the dominant cause of death in intensive care units of the industrialized world. As many as 800,000 cases of sepsis are admitted every year to American hospitals (comparable to the incidence of first myocardial infarctions), with half of those developing septic shock (1). Historically, the mortality associate...

Early goal-directed therapy reduced mortality and multiorgan dysfunction in severe sepsis or septic shock.

Severe sepsis and septic shock

Morbidity and mortality from sepsis remains unacceptably high. Large variability in clinical practice, plus the increasing awareness that certain processes of care associated with improved critical care outcomes, has led to the development of clinical practice guidelines in a variety of areas related to infection and sepsis. The Surviving Sepsis Guidelines for Management of Severe Sepsis and Se...

Severe sepsis and septic shock.

From the CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh (D.C.A.); and the Center for Experimental and Molecular Medicine, Division of Infectious Diseases, and Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterd...